research work VHH Design and Evaluation Designing VHH candidates for CAR T cells and testing whether their predicted confidence and binding surfaces survive re-evaluation. CART4-34 Manufacturing Improving lentiviral transduction for a selective CAR T cell therapy, with reagent screening and follow-up cell expansion. LLM Cell-Type Annotation Benchmarking LLM agents for reference-free cell-type annotation, with explicit checks for workflow failures and hallucinations. Bio-Sentry: Agent Guardrails A hackathon prototype connecting biological sequence screening to policy enforcement at an AI agent's tool-call boundary. class projects Multi-modal Sequence Encoding for AMPs Benchmarking peptide sequence encoders and multi-modal transfer learning for out-of-distribution generalization. CIS 5200 (Machine Learning). Learning to Walk with PPO Implementing PPO and a standing-to-walking curriculum for simulated locomotion. ESE 6500 (Learning in Robotics). State Estimation and Mapping Estimating orientation from inertial sensors and building LiDAR maps with quaternion and particle filters. ESE 6500 (Learning in Robotics). EMG-Controlled Communication Translating muscle contractions into Morse code with analog EMG circuitry, adaptive signal processing, and a Python game interface. BE 3100 (MAD Lab). Peptide Binder Design Designing IκBα-binding peptides for an induced-proximity concept within a Duchenne muscular dystrophy design challenge. BE 3060 (Cell Engineering). Computational CAR-T Design for Melanoma Designing TYRP1-binding miniproteins within a broader CAR-T cell engineering and delivery proposal. BE 3060 (Cell Engineering). Arduino Spectrophotometer An Arduino optical measurement instrument with calibration-based concentration estimation, an LCD interface, and a Ferrari F1-inspired enclosure. Music Genre Classification Classification model to predict the genre of a Spotify song based on its audio features. Final project for CIS 5450 (Big Data Analytics). Simplified Phase Vocoder Implementation of a simplified phase vocoder system in MATLAB to tune vocal input to the C Major scale. BE 3010 (Signals & Systems). Cell Movement and Morphology Analysis Tracking cell movement and changes in shape using microscopy images and computer vision. ENGR 1050 (Scientific Computing).
